Post by rabia373 on Mar 10, 2024 20:38:07 GMT -8
Home Changes in RNA can lead to cardiac hypertrophy Changes in RNA can lead to cardiac hypertrophy April , Published in:Health Research focusing on cardiac cells capable of undergoing remodeling is recognized at a conference abroad. Research focusing on cardiac cells capable of undergoing remodeling is recognized at a congress abroad Clara Nóbrega, an undergraduate student at the School of Physical Education and Sport (EEFE) at USP, had already received an Honorable Mention for her work presented at the rd International Symposium on Scientific Initiation at USP . But what she didn't expect was that the highlight would be even greater. Among the awarded works, Clara's project was one of five selected for oral presentation at the Undergraduate Research Symposium at Rutgers University, United States, from April to , Clara joined the Scientific Initiation program at the Laboratory of Biochemistry and Molecular Biology of Exercise at EEFE in her first year of graduation, under the supervision of professor Edilamar Menezes de Oliveira. Her studies focused on cardiomyocytes, which are cardiac cells capable of undergoing remodeling – such as physiological or pathological cardiac hypertrophy. These cells are cultivated in the laboratory and isolated to verify possible structural and biochemical changes and what mechanisms can trigger these changes.
The Exercise Biochemistry and Molecular Biology Laboratory focuses a lot of research on microRNAs, which are small molecules that block messenger RNAs, inhibiting protein synthesis. It is observed that microRNA-c*, studied by Clara, is sharply reduced in the left ventricle of animals undergoing aerobic physical training. The student explains that when a person exercises, their heart becomes stronger and more efficient. This allows the organ to pump the same blood flow with a lower heart rate, char Whatsapp Number List acterizing physiological hypertrophy. As animals subjected to aerobic physical training had a reduced number of microRNA-c*, it is believed that the inhibition of this molecule would lead to physiological cardiac hypertrophy. The student managed to simulate this change in cell culture, demonstrating that just by silencing this microRNA it would be possible to increase physiological cardiac hypertrophy, without requiring any other mechanism such as mechanical stress or biochemical stimulus. Innovation Usually, physiological cardiac hypertrophy is studied through a signaling pathway known as PIK-AKT-mTOR, activating pSK. The innovative part of this research is to use the other side of this path, a method not explored by many bibliographic references.
To date, Clara has worked with cell cultures. She has just started her master's degree, in which she intends to study animal models that have more organized and complex systems. Her intention is, in the future, to develop research with humans. The importance of this line of research is to obtain a treatment or gene therapy to inhibit microRNA-c* in the heart with the aim of restoring cardiac function in a person who has suffered a heart attack, for example. It is already known that it is possible to improve cardiac function, as well as reduce the risk of a new heart attack, through physical exercise. However, the researcher's concern is that a large part of the population that has suffered a heart attack is elderly and/or sedentary, which makes access to physical exercise difficult. She also highlights cases of heart attacks who are bedridden or patients suffering from other diseases that make it impossible to perform physical exercise, such as amputees due to complications from diabetes. The idea is not to replace exercise, but to try to find a therapy that, combined with it, enhances its results and obtains a faster effect, reducing hospital stays and more effectively reducing the harmful effects caused by heart disease.
The Exercise Biochemistry and Molecular Biology Laboratory focuses a lot of research on microRNAs, which are small molecules that block messenger RNAs, inhibiting protein synthesis. It is observed that microRNA-c*, studied by Clara, is sharply reduced in the left ventricle of animals undergoing aerobic physical training. The student explains that when a person exercises, their heart becomes stronger and more efficient. This allows the organ to pump the same blood flow with a lower heart rate, char Whatsapp Number List acterizing physiological hypertrophy. As animals subjected to aerobic physical training had a reduced number of microRNA-c*, it is believed that the inhibition of this molecule would lead to physiological cardiac hypertrophy. The student managed to simulate this change in cell culture, demonstrating that just by silencing this microRNA it would be possible to increase physiological cardiac hypertrophy, without requiring any other mechanism such as mechanical stress or biochemical stimulus. Innovation Usually, physiological cardiac hypertrophy is studied through a signaling pathway known as PIK-AKT-mTOR, activating pSK. The innovative part of this research is to use the other side of this path, a method not explored by many bibliographic references.
To date, Clara has worked with cell cultures. She has just started her master's degree, in which she intends to study animal models that have more organized and complex systems. Her intention is, in the future, to develop research with humans. The importance of this line of research is to obtain a treatment or gene therapy to inhibit microRNA-c* in the heart with the aim of restoring cardiac function in a person who has suffered a heart attack, for example. It is already known that it is possible to improve cardiac function, as well as reduce the risk of a new heart attack, through physical exercise. However, the researcher's concern is that a large part of the population that has suffered a heart attack is elderly and/or sedentary, which makes access to physical exercise difficult. She also highlights cases of heart attacks who are bedridden or patients suffering from other diseases that make it impossible to perform physical exercise, such as amputees due to complications from diabetes. The idea is not to replace exercise, but to try to find a therapy that, combined with it, enhances its results and obtains a faster effect, reducing hospital stays and more effectively reducing the harmful effects caused by heart disease.